A compounded formula that pairs prescription tretinoin with niacinamide and hyaluronic acid — so you get retinoid results with less of the dryness and irritation. Prescribed online, reviewed by licensed providers, shipped discreetly.
Tretinoin is the active that does the work; niacinamide and hyaluronic acid are there to keep your skin calm and hydrated so you can actually stick with it.
The most-studied retinoid still drives turnover, tone, and collagen — you don't trade away the results.
Helps reduce redness and reinforce the skin barrier, which is often what makes retinoids hard to tolerate.
Draws in and holds moisture to offset the dryness that can come with a retinoid.
Prepared through 503A partner pharmacies, with the tretinoin strength selected by a licensed provider.
Tretinoin + Niacinamide + HA is a compounded topical that pairs prescription tretinoin — a vitamin-A retinoid — with two supporting skincare actives in one cream. Niacinamide (vitamin B3) helps calm the skin and support its barrier; hyaluronic acid attracts and holds water for hydration.
The idea is simple: keep the proven retinoid results while softening the irritation, dryness, and peeling that lead many people to quit tretinoin in the first few weeks. Because it's compounded, it's prepared for you at a 503A pharmacy rather than pulled off a shelf.
Start your visit →The retinoid binds retinoic-acid receptors, speeding cell turnover and stimulating collagen to smooth tone and texture.
Vitamin B3 helps reduce redness and reinforce the skin barrier, so the retinoid feels less harsh as your skin adjusts.
Hyaluronic acid draws in and holds moisture, offsetting the dryness and flaking a retinoid can cause.
This formula is a strong fit for people who want retinoid results but have sensitive or dry skin, or who have struggled to tolerate tretinoin on its own. A provider confirms it's appropriate for your skin and history.
If plain tretinoin left you red, flaky, or tight, the buffered blend is designed to be easier to live with.
A gentler on-ramp for first-time retinoid users who want results without the roughest of the adjustment.
Early aging, uneven tone, dullness, and rough patches you'd like to smooth and brighten over time.
Because it contains tretinoin, avoid this blend if you're pregnant, trying to conceive, or breastfeeding — tell your provider.
A compounded blend — your provider selects the tretinoin strength that fits your skin:
Early on, mild "purging" — a brief uptick in breakouts as turnover speeds up — plus some dryness or peeling can still happen, though the niacinamide and HA are there to keep it gentler. This usually settles within a few weeks.
This blend contains tretinoin — do not use it if you are pregnant, planning to become pregnant, or breastfeeding. Tell your provider about pregnancy, all medications, and any skin conditions before starting.
Always use daily SPF. Stop and contact your provider if you develop severe irritation, blistering, or a rash.
A side-by-side look at the topical skin options available through ForbiddenRx. Your provider helps you choose what's right.
| Treatment | What it is | Best for | Use | Form | Rx required |
|---|---|---|---|---|---|
| Tretinoin + Niacinamide + HA | Compounded blend, buffered | Sensitive or dry skin | Nightly | Cream | Yes |
| Tretinoin | Prescription retinoid (vitamin A) | Acne + anti-aging | Nightly | Cream / gel | Yes |
| Hydroquinone | Prescription brightening agent | Dark spots & tone | Nightly | Cream | Yes |
| GHK-Cu | Copper-peptide repair | Firmness & recovery | Daily | Cream | Yes |
The best results come from consistency — and a gentler formula is one you're more likely to keep using. This blend's once-nightly routine is easy to keep, and your plan can flex as your skin builds tolerance.
Medically reviewed by ForbiddenRx Medical Affairs — Independent, licensed medical providers · Last reviewed July 2026. This page is educational and is not medical advice. It is not a substitute for professional medical advice, diagnosis, or treatment. Always talk with a licensed provider about your individual skin and health.
Complete a quick online visit. A licensed provider reviews your information and, if appropriate, your compounded blend ships discreetly to your door.
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